By S. H. Wright (auth.)
Advances in Comparative and Environmental Physiology presents complete, built-in studies giving sound, serious, and provocative summaries of our current wisdom in environmental and comparative body structure, from the molecular to the organismic point. the sector has now received the overseas prestige it merits and the association of a chain dedicated to it's very well timed in view of its genuine speedy improvement. Biologists, physiologists, and biochemists, independently in their easy clinical orientation, will locate this new sequence of significant interest.
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Fig. 8. Arrhenius plots of oxygen consumption as a measure of succinate dehydrogenase activity in the Richardson's ground squirrel under different physiological states. The number beside each line is the Arrhenius activation energy (Kcal mol-I) and the arrow indicates the Tc. Note the nonIinear plots for spring, summer, and cold- and warm-acclimated animals which did not gain weight and the linear plots in hibernating and aroused animals as well as in cold-and warm-acclimated animals which gained weight but have not yet exhibited hibernation.
These results raise questions as to the functional significance of these brain peptides in centrally modulating metabolism. It is possible that either the actions of these brain peptides are only peripheral or that a diffusive barrier prevents the access of these peptides to their CNS active sites following intraventricular injection. Regardless of these possibilities, antabolone has not yet been tested for the induction of hibernation and its effect in this respect remains uncertain. 2 The "Hibernation Induction Trigger" The existence of a bloodborne "hibernation induction trigger" (HIT) in hibernating rodents was first reported by Dawe and Spurrier (1969).
Furthermore, the stimulatory role of glucose on insulin secretion is absent, whereas that of the arginine on glucagon apparently persists in the hibernating hedgehog (Hoo-Paris et al. 1984). Taken together, these observations indicate a total shutdown of pancreatic beta cell function during hibernation in the hedgehog and the dormouse but a retention of quantitatively reduced alpha cell function under the same state. This suggests a differential thermosensitivity in stimulation-secretion coupling between the alpha and beta cells of the pancreatic islets.