By Frank J. Dixon
The Scripps study Institute, l. a. Jolla, CA. newest findings within the box of immunology. transformed define layout.
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Extra resources for Advances in Immunology, Vol. 69
The cytoplasmic tail of CD35is known to be essential for the signal transduction function of 5, but not for its structural role in promoting surface expression of the TCR complex. Efficient restoration of thymopoiesis in such reconstituted mice demonstrated that CD3[ was required mainly for cell surface expression of the pre-TCR, but not for pre-TCR signaling. , 1997). Taken together, these data suggest important structural differences between the aPTCR and the pre-TCR. The former is thought to have the following composition: TCRa-P, CDSys, CD36&, and ( - ~ T , J .
1992). These findings are in line with the view that a productive TCRP rearrangement can somehow prevent further rearrangements at the TCRP locus. , 1989), which enforce almost complete inhibition of endogenous VP (D)JP rearrangements, whereas DP -+ JP rearrangements are essentially unimpaired. , 1989). , 1993). , 1995). Thus, it appears that rearrangements at the TCRa locus continue on both alleles until a receptor is formed that can bind to thymic MHC molecules. , 1995). , 1997) (see Section 111,B).
Whether the effect of y8-expressing cells is brought about by direct thymocyte- MOLECULAR AND CELLULAR EVENTS IN THYMOCYTE DEVELOPMENT 33 thymocyte contacts, by secretion of cytokines that act on pre-T cells, or indirectly by activation of thymic stromal cells, which, in turn, stimulate the entry of CD4-CD8- thymocytes into the CDdCD8 differentiation pathway, has remained obscure. Moreover, it is not clear whether DP thymocytes generated in this way are "genuine" DP thymocytes with the potential to mature into functional T cells (if they could express a functional TCR) or whether they are some aberrant, dead-end cells that just happen to express CD4 and CD8 coreceptors.