By J.M. Parry, C.F. Arlett
This selection of sixty nine papers investigates 'in vitro' metabolic activation arrangements for 2 particular pairs of chemical analogues, benzidine (BZD) with 4,4-diaminoterphenyl (DAT) and 4-dimethyl-aminoazobenzene (DAB) with 4-cyanodimethylaniline (CDA). The arrangements chosen have been uninduced rat liver (using rats of a similar pressure because the bioassay). Aroclor-induced rat liver, uninduced mouse liver (using an identical mouse pressure as utilized in the 'in vivo' cytogenetics assays), and uninduced bird. the main bulk of the assays defined within the learn concerned using huge universal batches of those fifty nine arrangements. The learn used to be backed by way of the uk Environmental Mutagen Society (UKEMS) and may stand as a tremendous landmark in genetic toxicology.
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Extra resources for Comparative Genetic Toxicology: The Second UKEMS Collaborative Study
K. P. (1978). Study of metabolic activation of chemicals using microorganisms. 1. Effect of the inducers of microsomal systems. U. A. (1978). Studies of mutagenic activity of dioxydine. Soviet Genetics 14: 640-647 Friedrich, U. and Nass, G. (1983). Evaluation of a mutation test using S49 mouse lymphoma cells and monitoring simultaneously the induction of dexamethasone resistance, 6-thioguanine resistance and ouabain resistance. Mutation Res. 110: 147-162 Fritz-Niggli, H. (1954). The production of mutations with carcinogenic substances.
1979). Effectiveness in the carcinogenicity prescreening. Partial comparison of the ·bacterial mutagenicity test (Ames), the thymidine incorporation inhibiting screening system (Amlacher) and the promoting activity test (Danz). Arch Geschwulstforsch. S. E. (1983). Activation of mammalian carcinogens to bacterial mutagens by microsomal enzymes from a pelecypod mollusk, Mercenaria mercenaria. Mutation Res. , Anderson, D. and Paton, D. (1978). Thiophene analogues of the carcinogens benzidine and 4-aminobiphenyl: evaluation in vitro.
And Paton, D. (1982). Comparisons between carcinogenic potency and mutagenic potency to Salmonella in a series of derivatives of 4-dimethylaminoazobenzene (DAB). Mutation Res. M. and Podobna, E. (1983). Sensitivity of two Chinese hamster cell lines in SCE induction by a variety of chemical mutagens. Mutation Res. F. and Santi, 1. (1980). DNA damage and repair induced in vivo by benzidine treatment. Boll. Soc. tal. Biol. Sper. F. and Santi, L. (1981). Evaluation of DNA damage by alkaline elution technique after in vivo treatment with aromatic amines.