Cytomegalovirus: Biology and Infection by Monto Ho

By Monto Ho

Although there are various very good present experiences on one or one other element of cytomegalovirus, the final finished remedy of this topic was once that of Krech et al. (197la). In view of the superb advances within the virological, epidemiologic, and medical wisdom of cytomegaloviruses, an up to date ebook is required. one of these paintings may still conceal many components of craftsmanship and a voluminous technical literature. every one region could have been reviewed and analyzed via employees extra specialist than myself. besides the fact that, i've got launched into the full enterprise by myself so as to reach solidarity and continuity during this publication, features that aren't simply completed within the extra well known multiauthored works. i've got attempted to study the Iiterature and supply a serious precis for every region mentioned. to do that, I offer as a lot of the first information of the proper works as wanted and never simply the qualitative conclusions. unavoidably, the move of the narrative should be interrupted through dry evidence and figures. despite the fact that, such info is vital to make this a significant reference paintings. yet for these now not drawn to such info, i've got supplied at what i'm hoping are an important issues evaluations and summaries. This publication isn't an exhaustive evaluation of the entire literature. this can be most likely no Ionger attainable or perhaps fascinating. by means of choice, even though, one runs the danger of getting overlooked or overlooked vital papers. i'm keenly conscious of this, and that i desire to ask for forgiveness for such oversight, if that's possible.

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Example text

Factors binding to distal sequences may function ultimately by contacting a factor(s) more proximal to the transcription initiation site such as TFIID (see Fig. 2) and RNA polymerase II. There is little significant homology between the regulatory regions of beta- and alphaherpesviruses with the exception of the SPI binding domain and a region in pseudorabies virus with a distant homology to the 18-bp repeat of CMV (Campbell and Preston, 1987). Even though human CMV and HSV have a similar genome organization and replicate in many of the same cells, these viruses have evolved to have unique cognitive and regulatory domains upstream of their IE genes.

Altematively, the protein may mirnie a normal cellular function. 385 map units (UL57) is colinear and has homology with the HSV ICP8 gene (Fig. 4A). , 1987). , 1987). In HSV, ICP8 is required for DNA replication (Chiou et al. , 1985; Conley et al. , 1981; 0' DonneU et A '1i5iib' Componenta Ul --f-----------"'-- - ' - -UL- " " , __________ TR,. :=.. ,... , 7. :\. (li-,"-·• ____,,_........ 19Lff ...... , .... ", "•"•"•"• ··-... HILf! LfJ ...... ~ HXLFJ . D ud-n ... 4. Early and late genes in the long and short components of the human CMV genome.

These observations suggest that complete processing of these human CMV viral RNAs requires either a viral gene product that is not available until after viral DNA synthesis or a cellular gene or product that is induced only afterviral DNA synthesis. Therefore, the precursor viral RNA is retained in the nucleus at ear1y times. There are presumably other mechanisms ofposttranscriptional regulation that control either the stability of viral RNAs, the transport of human CMV mRNAs to the cytoplasm, or the translation of these RNAs in the cytoplasm.

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