Design and Analysis of Vaccine Studies by M. Elizabeth Halloran

By M. Elizabeth Halloran

Widespread immunization has many various types of results in members and populations, together with within the unvaccinated members. The problem is in figuring out and estimating all of those results. This publication offers a unified conceptual framework of different results of vaccination on the person and on the inhabitants point. The publication covers many various vaccine results, together with vaccine efficacy for susceptibility, for disorder, for post-infection results, and for infectiousness. The booklet comprises equipment for comparing oblique, overall and total results of vaccination courses in populations. issues contain loved ones experiences, comparing correlates of immune security, and functions of informal inference. fabric on innovations of infectious ailment epidemiology, transmission versions, informal inference, and vaccines presents heritage for the reader. this can be the 1st ebook to give vaccine assessment during this complete conceptual framework.

This ebook is meant for colleagues and scholars in data, biostatistics, epidemiology, and infectious ailments. such a lot crucial techniques are defined in basic language available to epidemiologists, by means of technical fabric available to statisticians.

M. Elizabeth Halloran and Ira Longini are professors of biostatistics on the collage of Washington and the Fred Hutchinson melanoma examine heart in Seattle. Claudio Struchiner is professor of epidemiology and biostatistics on the Brazilian university of Public healthiness of the Oswaldo Cruz beginning in Rio de Janeiro. The authors are in demand researchers within the zone. Halloran and Struchiner built the research designs for based happenings to delineate oblique, overall, and total results. Halloran has made contributions on the interface of epidemiological tools, causal inference, and transmission dynamics. Longini works within the quarter of stochastic procedures utilized to epidemiological infectious disorder difficulties, focusing on the mathematical and statistical concept of epidemics. Struchiner has contributed to figuring out the function of transmission in studying vaccine effects.

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Matching by transmission characteristics might be desirable (Hayes et al 1995). Interpretability and general applicability of quantitative results to other settings may be limited, although qualitative trends might hold (Halloran and Struchiner 1995). Comparisons across communities would also allow study of other biological questions. For example, vaccines might contain only particular serotypes or strains of an organism. Widespread vaccination could allow the expansion of non-vaccine serotypes that had been less important before vaccination (Lipsitch 2000; Singleton et al 2007; Peters and Poehling 2007) or put evolutionary pressure on the existing strains.

T) ≤ 1. Let I j (t) = 1 if person j is infectious at time t and I j (t) = 0 otherwise. A person is infectious immediately after becoming infected (no latent period). Let Si (t) = 1 if person i is susceptible at time t and Si (t) = 0 otherwise. We define both sets of these processes to be left continuous. Thus, I j and Si are predictable processes (Bremaud 1981). 13) where Ht is some history (Bremaud 1981). Informally, by a history we mean some observed information arising from various processes on the time interval 38 2 Overview of Vaccine Effects and Study Designs (0,t].

The causal inference framework based on potential outcomes induces an inherent heterogeneity in the population. In some infectious disease papers, the four types of people are called never infected, harmed, protected, and always infected. The four different types of people are latent groups that cannot be identified without further assumptions. 4 Causal Inference and Vaccine Effects 17 become infected. If we make the assumption that the vaccine does not harm people, that is, there are no individuals in the harmed stratum, then we know that the infected vaccinated person must be in the doomed stratum.

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